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Cleveland Star
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Early immune response may help combat hit-and-hide cancer viruses
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Washington, Jan 16 : Retroviruses such as HIV and HTLV-1 don't hit-and-run, they hit-and-hide. Now, researchers at Ohio State University have revealed that an early and strong immune response might help curb the infection that is likely to last long.
According to the researchers, cancer viruses slip into host cells and insert their own DNA into the cell's DNA, and from this refuge they establish an infection that lasts a lifetime.
"Our findings indicate that if the immune system could respond strongly to HTLV-1 and kill infected target cells early, it may inhibit the virus's ability to establish reservoirs of infected cells and make the infection more manageable later," said principal investigator Michael Lairmore, a professor and chair of veterinary biosciences and a cancer researcher at OSUCCC-James.
"This study tells us that the more we know about the earliest events of infection, the more it will help us develop vaccines and might block those events," Lairemore added.
Lairmore and his colleagues examined HTLV-I infection in rabbits that were treated with the drug cyclosporin A, which is commonly used to suppress the immune system in people following organ transplantation.
They compared animals treated with this drug prior to viral infection with those given the drug one week after infection.
In animals given the immune-suppressing drug first, the virus flourished. The number of virus copies jumped to 200 per 10,000 immune cells (lymphocytes), compared with 40 per 10,000 immune cells in control animals (these were infected with the virus but not given the drug).
After a week or two, the number of virus copies fell, ranging from 113 to 160 for remainder of the 10-week experiment.
In the animals that were given the virus first and then the immune-suppressing drug a week later, on the other hand, the virus languished.
"The first experiment told us that if the immune system is suppressed, the viral load goes up - and we expected that," said Lairmore.
"The second group was the surprise. Their viral load was low from the start, and it stayed that way. We didn't expect that. We thought the virus would recover and come back up.
"Collectively, our findings indicate that the immune system plays a key role in controlling HTLV-1 spread during early infection, which has important implications for a vaccine against this virus and for therapy for HTLV-1-associated diseases," he added.
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Cleveland Star
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The Cleveland Star is essentially a local Cleveland newspaper, but with a national and international perspective, designed to provide readers with a one-stop shop for Cleveland, national US, regional, and world news coverage, weather and sports information, with live updates on breaking business stories, and what's happening in the financial markets.
The biggest advantage we have is that we are an online newspaper, which means we are constantly refreshing our stories as more and more information comes to hand. Often when a story breaks the initial details are sketchy.
We and our sources around the world work hard to gather more information, verify facts, and provide a perspective of the major stories. Expert opinion often accompanies our articles to better inform readers, and provide a more complete understanding
of the news we deliver.
Financial markets and business reports are regular features as we pin down what's happening, and constantly refresh stock market indice readings, dollar currency rates, and breaking business news reports. Our world sports coverage is a priority, as is our regional news.
We like to think if you're looking for breaking news out of Cleveland, Ohio, the United States, or the world, you'll look for it first at the Cleveland Star. |
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| Wyndham Miami Beach Resort |

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First impressions are so important for a hotel guest's stay. Ironically when one thing goes wrong early on inevitably a guest's...
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